A recent study highlights how genetic changes in epigenetic regulator genes shape immune responses in bladder cancer, potentially guiding more personalised therapies.
Posted on in Health & Medicine, Cell Biology, Molecular Biology & Research
A new study by CSIR-Centre for Cellular and Molecular Biology indicates that minor mistakes while synthesising proteins can be advantageous for cells under stress by enabling them to sense and react to toxic molecules. This establishes how nature achieves precision and yet remains flexible, enabling cells to evolve and modify themselves even in very adverse conditions by way of precision-tuned molecular mechanisms.
Posted on in Health & Medicine, Cell Biology, Molecular Biology & Research
The brain, a biological engineering wonder, depends on a delicately balanced system of cells, signals, and defense barriers to work in harmony. For decades, researchers have studied neurodegenerative diseases like Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS), and Frontotemporal Dementia (FTD) with a near-exclusive focus on neurons, the brain’s information processors. However, what if the earliest signs of damage occur not within neurons, but in the blood vessels that support and protect them?
Researchers from Jadavpur University have developed classification-based machine-learning models for toxicity assessment of plastic packaging associated chemicals. These models can efficiently predict the toxicity of chemicals thereby providing a valuable tool for researchers as well as regulatory bodies, overcoming health concerns.
A recent study from the Indian Institute of Science (IISc), Bangalore, has identified a new key player among brain regions, the superior colliculus (SC), in guiding skilled forelimb movements.
A collaborative research by scientists from the National Centre for Biological Sciences (NCBS), Bangalore, and the Institute of Functional Genomics, University of Montpellier, INSERM, CNRS, France, has recently solved the structures of the complex brain receptor—metabotropic glutamate receptor 5 (mGlu5). They describe the binding mode of small molecules known to increase receptor activity, paving the way for new avenues in drug design.
Scientists at the National Institute of Science Education and Research (NISER), Bhubaneswar, have uncovered the molecular mechanism behind Gram-negative bacteria’s resistance to the drug PC190723, revealing how intra-molecular interactions in proteins, such as salt bridges, prevent the drug from binding effectively.
Posted on in Health & Medicine, Cell Biology, Genetics & Research